Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear
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چکیده
منابع مشابه
Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear.
Recent studies using lesion, infusion, and unit-recording techniques suggest that the infralimbic (IL) subregion of medial prefrontal cortex (mPFC) is necessary for the inhibition of conditioned fear following extinction. Brief microstimulation of IL paired with conditioned tones, designed to mimic neuronal tone responses, reduces the expression of conditioned fear to the tone. In the present s...
متن کاملInactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction.
Rats were subjected to one or two cycles of context fear conditioning and extinction to study the roles of the prelimbic cortex (PL) and infralimbic cortex (IL) in learning and relearning to inhibit fear responses. Inactivation of the PL depressed fear responses across the first or second extinction but did not impair learning or relearning fear inhibition (experiment 1). Inactivation of the IL...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2006
ISSN: 1072-0502
DOI: 10.1101/lm.306106